For the 24th consecutive year, the Pan American Health Organization (PAHO) has published the report Health Situation in the Americas: Core Indicators featuring the latest information on key indicators for the Region of the Americas. This 2018 edition includes data on the 82 core indicators for the countries, territories, and sub regions of the Americas, grouped into the following categories: demographic-socioeconomic, health status, risk factors, service coverage, and health systems. Information is also presented on 22 indicators of the Sustainable Development Goals (SDGs). When used as part of a monitoring and evaluation process, indicators are an essential element in the production of evidence in health to inform decision-making. With the continuing advances in technology, data collection has become more frequent and timely, making monitoring and follow-up possible on a routine basis at the global, regional, subregional, national, and subnational levels.