In COVID-19 and Girls’ Rights Series, With and For Girls shares learning, resources, knowledge and calls to action regarding the impact of COVID-19 on girls globally. It draws from the Collective partners, girl leaders at the grassroots level and the leadership team at Purposeful, within which With and For Girls is a programme. Part Five of the series explores the wide ranging and devastating impacts of COVID-19 on the sexual and reproductive health and rights (SRHR) of girls. The team spoke with two girl-led and girl-centred sexual and reproductive health and rights providers, Roots of Health and Asociación AMA.