Across every sphere, from health to the economy, security to social protection, the impacts of COVID-19 are exacerbated for women and girls. This policy brief focuses on each of these issues in turn, exploring how women and girls’ lives are changing in the face of COVID-19, and outlining suggested priority measures to accompany both the immediate response and longer-term recovery efforts. However, women will also be the backbone of recovery in communities. The policy brief emphasizes three cross-cutting priorities: 1) Ensure women’s equal representation in all COVID-19 response planning and decision-making; 2) Drive transformative change for equality by addressing the care economy; 3) Target women and girls in all efforts to address the socio-economic impact of COVID-19.